Texes Social Studies Practice Exam 2025 – Complete Test Prep Guide

The introduction of European diseases to the Americas was a significant impact of the Columbian Exchange because it drastically affected the Native American populations who had no prior exposure or immunity to these diseases. This led to devastating epidemics, resulting in the loss of a vast majority of Indigenous people across the continent. The arrival of pathogens such as smallpox, influenza, and measles decimated communities, undermining their societies and significantly altering the demographic landscape of the Americas.

This impact is crucial as it set the stage for European colonization and exploitation, as the weakened populations found it challenging to resist foreign encroachment and control. Understanding this aspect of the Columbian Exchange provides insight into the long-term effects of early contact between Europe and the Americas, which reshaped the world in numerous ways, including the social, cultural, and economic structures in both continents.